3a; Additional file 1: Table S9) in ADAD brains compared to LOAD. We observed the same cellular differences when we corrected for CDR at death (β = − 0.12; p = 2.11 × 10−03 for neurons and β = 0.13; p = 6.29 × 10−04 for astrocytes; Table 3; Fig. 3b, c). In summary, our results indicate that ADAD individuals present a higher neuronal loss even in the same stage of the disease, suggesting that in ADAD neuronal death plays a more important role in pathogenesis compared to sporadic AD, in which other factors such as inflammation or immune response may be involved.
