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Chunk #12 — Results — Postpartum female mice show increased susceptibility to SCUS-induced depression-related behaviors

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The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice.
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= 0.011), stress (F (1, 30) = 9.080, P = 0.005) and fertility condition × stress interaction (F (1, 30) = 6.980, P = 0.013) on sucrose preference. Virgin mice showed no changes of preference for sucrose (P = 0.995), while postpartum mice demonstrated reduced (P = 0.001) preference in the SPT compared to non-stressed mice. Meanwhile, the preference for sucrose was also reduced in stressed postpartum mice compared to stressed virgin mice (P = 0.003) (Fig. 3c). We also found a significant effect of fertility condition (F (1, 30) = 4.288, P = 0.047), stress (F (1, 30) = 13.350, P = 0.011) and fertility condition × stress interaction (F (1, 30) = 7.404, P = 0.013) on immobility in the FST. Further analysis indicated that stressed virgin mice had no significant immobility time (P = 0.924), while stressed postpartum mice had more immobility time (P < 0.001) compared to non-stressed mice. The immobility time was also elevated in stressed postpartum mice compared to stressed virgin mice (P = 0.008) (Fig. 3c).