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Chunk #8 — 1. Introduction

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Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
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We conducted a genetic association study of both GAD genes in a sample of Western European origin that is more culturally and genetically homogeneous than samples used in previous studies. We examine the association of the GAD1 and GAD2 genes with AD and relevant alcohol-related traits as well as possible gender specific effects in these genetic associations.