DNase I hypersensitive sites (DHSs) are regions where DNA degradation by enzymes like DNase I occur more frequently than elsewhere. As a result, DHSs can mark active transcription regions across genome and these patterns are known to be tissue or cell specific. The ENCODE project analyzed the DHSs in 125 human cell lines with the intention of cataloging human regulatory DNA [38]. In this section, we applied GPA to assess how bladder cancer [39] risk associated SNPs are enriched in DHSs region across these 125 human cell lines.
