In sum, these analyses underscore the importance of using neurobiologically informed annotation datasets and neuroimaging data to further elucidate biological substrates underlying genetic overlap between traits characterising AUD development. While the current study is informative, it is not without limitations. First, analyses were restricted to samples of European ancestry and cannot be generalised to other ancestral populations, which are greatly underrepresented in GWAS research. 75 Current initiatives to extend GWAS of alcohol use traits across ancestral populations may help address this limitation in future research. 76 Second, the sample size of the AUD GWAS, though one of the larger GWAS of AUD diagnosis to date, was less well‐powered relative to sensation seeking and alcohol consumption. Sample size discrepancies across traits and related differences in power to detect associations may have influenced findings to some extent.
