in aggregate, the full set of trans-eQTLs demonstrated significantly greater replication than expected by chance (Wilcoxon rank sum test on association P values compared to uniform; P ≤3.05 ×10−5 for 16 tests in matched tissues; P ≤2.2 ×10−16 for 2,176 tests across all four TwinsUK tissues). In addition, aggregate replication of trans-eQTLs was significantly stronger for matched tissue types than for unmatched tissue types (Wilcoxon rank sum test; P ≤1.54×10−4; Extended Data Fig. 13b).
