paperKB
coga / coga-kb
Help
Sign in

Chunk #9 — Materials and Methods — Intravenous morphine dose data from opioid-naïve pediatric surgery patients

Source
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Embedded
yes

Text

Children 4–18 years old who received intravenous morphine during a tonsillectomy and adenoidectomy at the Children’s Hospital of Philadelphia (CHOP) were identified using the Anesthesia Information Management system (CompuRecord, Phillips Medical Systems, Andover, MA). All surgeries were performed between November 1, 2001 and December 1, 2009. Exclusion criteria included obstructive sleep apnea, a combination of tonsillectomy and adenoidectomy with another procedure, or administration of other intraoperative anesthetics. While recovering in the Postanesthesia Care Unit (PACU), children received additional intravenous morphine (in 25–50 μg/kg increments) to control their pain. The CHOP IRB approved collection of these data.