reported previously for untreated CaMKIICre(+):Girk2 fl/fl mice6. Dorsal CA1 pyramidal neurons from CaMKIICre(+):Girk2 fl/fl mice expressing GIRK2a or GIRK2c exhibited significantly larger baclofen-induced currents (Fig. 7B,C). Indeed, currents measured in dorsal CA1 pyramidal neurons expressing GIRK2a or GIRK2c were notably larger than those reported previously in wild-type or CaMKIICre(−):Girk2 fl/fl controls6, 15, suggesting that the GIRK2 isoforms were over-expressed in these neurons.
