Chunk #15 — RESULTS — Distribution of CNVs Across Disorders — Disorder-specific CNVs and Broad Criteria for Assignment of Disorders

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Distribution of disease-associated copy number variants across distinct disorders of cognitive development.

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Using the broad criteria, the extent of disorder-specific genes was substantially reduced. Using broad criteria, disorder-specific CNVs and genes were reduced in number: ID (2 CNVs, 40 genes; 6.7% of ID CNVs), ASD (3 CNVs, 5 genes, 10.7%), and schizophrenia (9 CNVs, 26 genes, 42.9%). Of note, given the high degree of overlap across disorders using broad criteria, schizophrenia was the disorder that stood out in greatest distinction from ID and other conditions.