GAD1 but not GAD2. Lappalainen et al. (2007) genotyped 13 SNPs for GAD2 in a sample of 113 Russian males with AD and 100 controls and found modest association for a functional marker, rs2236418 (−243 A > G). However, in the same report, these authors reported they were unable to replicate this association using two other samples: European–American with AD and U.S. college students with drinking problems. Therefore, the role of GAD genes in AD and alcohol-related problems requires further study.
