The rate of nicotine metabolism has been shown to influence tobacco smoking patterns [1, 2]. For example, adult slow nicotine metabolizers smoke fewer cigarettes daily and weekly [3–5] and have lower smoke exposure as measured by expired air carbon monoxide and plasma nicotine levels, than normal and fast metabolizers [4]. Consumption patterns, as well as smoking topography (i.e., how each cigarette is smoked), influence body nicotine and toxicant concentrations and have implications for tobacco addiction and health harm [6–8].
