The PGC-PTSD Freeze 2 dataset (PGC2) includes 60 ancestrally diverse studies from Europe, Africa and the Americas. Of these, 12 were already included in Freeze 110. Study details and demographics can be found in Supplementary Data 1. PTSD assessment was based either on lifetime (where possible) or current PTSD (i.e. including participants with a potential lifetime PTSD diagnosis as controls), and PTSD diagnosis was established using various instruments and different versions of the DSM (DSM-III-R, DSM-IV, DSM-5). For GWAS analyses, all studies provided PTSD case status as determined using standard criteria and control subjects not meeting the PTSD diagnostic criteria (see Supplementary Data 1 for additional exclusion criteria). The majority of controls was trauma-exposed. A detailed description of the studies included is presented in Supplementary Methods. We have complied with relevant ethical regulations for work with human subjects. All subjects provided written informed consent and studies were approved by the relevant institutional review boards and the UCSD IRB (protocol #16097×).
