S1A and S1B). In contrast to this BD and brain region-specific difference in miR-34a expression, based on the recent identification by GWAS of a new susceptibility locus within the first intron of ODZ4 where miR-708 is encoded16, which is predicted to target both ODZ4 itself and CACNA1C, the latter of which has shown multiple association with neuropsychiatric disorders53, we also measured miR-708 in the same cerebellum samples from BD individuals (Figure S1C), but did not see any differences compared to the healthy controls. Therefore, we did not pursue the investigation of miR-708 targets and focused our study on miR-34a.
