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Chunk #37 — METHODS — BioInformatics Analysis

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Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.
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Ingenuity Pathway Analysis was used to identify the common function and pathways among the genes that showed significant change in DNA methylation by alcohol. Ingenuity uses a curated database to predict the functions, canonical pathways, and networks from the Ingenuity Knowledge base (IPKB). Fischer's exact test was used to identify the significant functions and pathways relevant to the genes.