fast transients gated by AMPA receptors. Intracellular MK801 had little effect on the up-state dynamics of FS neurons consistent with the reduced expression of NMDA receptors expression in this subpopulation of PFC interneurons (Wang and Gao, 2009). Despite these differences in functional NMDA receptors, bath application of ethanol reduced up-state duration by approximately the same amount in both pyramidal and interneurons. This finding again underscores the highly interconnected nature of prefrontal neurons and how they contribute to network activity.
