Globally, alcohol is estimated to be the seventh-leading risk factor in 2016 in terms of DALYs. In the same year, alcohol use was estimated to have caused 99·2 million DALYs (88·3 million to 111·2 million), accounting for 4·2% (3·7–4·6) of total DALYs. This is a larger share of total burden than previously reported, driven primarily by changes made to both the exposure and RR models. This burden is distributed unequally among the sexes and regions. When decomposed by sex, alcohol use accounts for 6·2% (5·6–6·9) of total DALYs among men and 1·7% (1·4–2·0) of total DALYs among women. When decomposed by region in 2016, alcohol use accounts for 13·9% (11·5–16·8) of age-standardised DALYs in eastern Europe, 4·0% (3·4–4·6) of age-standardised DALYs in Southeast Asia, but only 0·8% (0·6–1·0) of age-standardised DALYs in the Middle East. Alcohol use attributable DALYs have also increased by more than 25% over the years 1990–2016, driven primarily by increased consumption in South Asia, Southeast Asia, and Central Asia, among both men and women. Globally, alcohol use exposure has increased by 15·2% (8·7–22·6) over that time
