Chunk #10 — Introduction — 1. Epigenetic Regulation due to Histone Covalent Modifications — 1A. Role of Histone Acetylation and Deacetylation in Transcriptional Regulation
neurodegenerative disorders (Valor, Viosca, Lopez-Atalaya, & Barco, 2013). Landmark studies have shown that CBP is important for memory consolidation using a rodent model of Rubinstein-Taybi syndrome (RTS) (Korzus, Rosenfeld, & Mayford, 2004). Mutations in CBP have been shown to impair long-term potentiation and memory and alter acetylation leading to cognitive and memory deficits (Barrett et al., 2011; Alarcón et al., 2004).
