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Chunk #9 — Results — Study Populations

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A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
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Consistent with previous reports, age of onset of daily smoking was inversely related to level of dependence in the present sample. Age of onset and FTND score were correlated, r(2135) = −0.18, P<0.001, and dichotomized age of onset and FTND were highly associated (χ2 = 51.6, 1 df, P<0.001). In early onset smokers, 24.2% had low FTND scores compared with 38.7% of late onset smokers.