Unsupervised hierarchical clustering of DMRs between B-iPSC and F-iPSC easily distinguished iPSC from ntESC and fESC, which cluster together (Fig. 3a). B-iPSC cluster nearer to ntESC and fESC than do F-iPSC, which represent a strikingly separate cluster. These data indicate that the methylation patterns of ntESC are more like fESC than are either iPSC.
