[derived from GWASs containing 36,989 cases and 113,075 controls and identifying 108 independent loci (Schizophrenia Working Group of the Psychiatric Genomics, 2014)] is associated with reward-related brain function, but a PRS derived for depression (derived from GWASs containing 9,240 cases and 9,519 controls identifying no genomewide significant SNPs (Major Depressive Disorder Working Group of the Psychiatric et al., 2013) is not, whether this is indicative of genetically-conferred disorder specificity or simply a confound of the power of the discovery GWAS cannot be disarticulated. However, as the field continues to advance and more well powered psychiatric GWAS are conducted across disorders, comparisons of PRS across disorders to detect shared and specific polygenic variability may prove informative.
