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Chunk #34 — Methods — Duke Neurogenetics Study (DNS; N = 312) — BOLD fMRI corticolimbic reactivity paradigm

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Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.
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participants view a trio of geometric shapes (i.e., circles, horizontal and vertical ellipses) and select which of 2 shapes displayed on the bottom matches the target shape presented on top. Each control block consists of 6 different shape trios presented for 4 seconds with a fixed inter-stimulus interval of 2 seconds, comprising a total block length of 36 seconds. The total paradigm is 390 seconds in duration. Reaction times and accuracy are recorded through an MR-compatible button box.