We estimated the enrichment of h2SNP in genes specifically expressed in 44 tissues in the GTEx47 project using the partitioned h2SNP framework in LDSC-SEG46 and an LD reference panel generated with EUR individuals from 1000 Genomes68. We obtained tissue-specific gene expression annotations in GTEx tissues from LDSC-SEG and then estimated the enrichment of h2SNP in annotations that corresponded to each of the tissues together with 52 annotations in the baseline model69. We report the P value of the one-sided test of enrichment of h2SNP in genes specifically expressed in each tissue against the baseline.
