= 0.033). The test continued to deviate significantly from chance at a range of thresholds, suggesting consistent signal between the PGC results and 23andMe. For the 82 independent SNPs with nominal p-values less than 1×10−5 in 23andMe, the p-value for the sign test was p=2×10−6 with the odds ratio for a sign match being 10.6 (95% CI= 3.5–37.1). Furthermore, the effect sizes for the top independent 23andMe loci are correlated with the effect sizes of those SNPs in PGC (removing loci with MAF < 5% to avoid highly variable values). This correlation peaks at the 39th peak 23andMe locus with 68% correlation (p=2.5×10−9). Additionally, we calculated the genetic correlation between the two datasets using LD score regression20 and found the two major depression datasets were highly and positively correlated (rg=0.725, SE=0.093, p=7.05×10−15).
