(p < 0.05) was found (data not shown). If the clinical diagnosis phenotype tested was “alcohol dependence or depression” (both by DSM-IV criteria), only 4 SNPs that we tested from the CRHR1 gene, rs242924, rs1396862, rs878886, rs878887, resulted in statistical significance (p < 0.05) in the genetic association test. It is plausible that there are different gene variations or different combination of polymorphisms in the CRHR1 gene that moderate the development of depression and alcohol dependence after stressful life events.
