Our sample comprised 36,678 individuals of European ancestry from the UKB, all study participants whose data were available as of September 1, 2020. All UK Biobank (www.ukbiobank.ac.uk) participants provided written informed consent, and the North West Multi-Center Ethics committee granted ethical approval. Participants provided demographic and health information via touchscreen questionnaires. A nurse conducted a medical history interview, which included self-report of medical diagnoses and other conditions or life events that were used to evaluate eligibility to participate (study details are available at https://www.ukbiobank.ac.uk/media/gnkeyh2q/study-rationale.pdf). Vital signs were obtained, and BMI was calculated as weight (kg)/height2 (m).
