Of the two studies that have assessed HOMER1 and addiction disorders, one reported significant association with HOMER1 and cocaine dependence,27 while the other failed to find any association with alcoholism.28 To date, no investigation has examined HOMER1 and heroin dependence and no studies have examined the role of DLG4 and addiction. Thus, the current study adds to the existing literature and moreover highlights the need of further exploring genetic variants related to the post-synaptic density and glutamate transmission in drug dependence.
