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Chunk #43 — DISCUSSION

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MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes.
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estimate “recombination rates” within each dataset and allow “mutation rates” to vary. These parameters capture not only intrinsic characteristics of the markers and regions being examined, but also—for example—the genetic distance between the samples being imputed and the reference panel (which can impact apparent “recombination rates”) and differences in genotyping protocols between the two samples (which can impact apparent “mutation rates”).