our studies (miR-369-3p, miR-34c-5p, miR-203, miR-146a, miR-194, and let-7 family members, Table 1, column B). This is statistically highly significant (p = 0.00022), as it is expected that only one miRNA would be common between the two lists by chance (as empirically determined after 100,000 Monte Carlo simulations). This underscores the importance of miRNA upregulation due to alcohol exposure and suggests a consistent involvement of multiple miRNAs in mediating neuroadaptations that could potentially contribute to alcohol dependence.
