NSWBTRC samples were genotyped using the UK Biobank Axiom® Array (ThermoFisher Scientific, Waltham, MA, U.S.A.). Before imputation, palindromic SNPs and SNPs with genotyping rate <95%, minor allele frequency < 1%, or Hardy-Weinberg equilibrium P value < 1E-4 were excluded. Genotype data were imputed by using the TOPMed Imputation Server73. Eagle v274 was used to phase the genotypes, and Minimac4 v1.2.473 was used for imputation. Data from the Trans-Omics for Precision Medicine (TOPMed r3)75 were used as the reference genomes. Variants with imputation R2 > 0.995 were retained for use in demultiplexing (see below).
