In an effort to further elucidate the possible origin of the signal of our best hit, we investigated the LD between rs4714329 and the variants within the nearby genes (RP11-552E20.1, TDRG1, LINC00951 and LRFN2) utilizing the GWAS variant data of the CRIME cohort as well as the HapMap3 project data and the 1000 Genomes Pilot 1 data (Supplementary Information). The strongest LD was observed between rs4714329 and several variants of the LINC00951 gene, consistently in all three data sets. In addition, the CRIME sample LINC00951 gene variants (rs17619142 and rs17619309) revealed nominal association with ASPD (OR of 1.18 and 1.5, and P value of 0.002 and 0.159, respectively), which supported the role of LINC00951 as the strongest candidate of the nearby genes for the signal origin.
