Although Wip1 has been shown to be induced after a variety of stresses, most of the studies on this phosphatase have focused on its role in the DDR and in the response to oncogenic stress. Wip1 directly binds to, dephosphorylates, and inactivates a number of stress signaling proteins, leading to increased tumorigenesis and inhibition of the processes of DNA repair, cell cycle arrest, and apoptosis. Recent studies have shown that Wip1 also suppresses inflammatory signaling, facilitates senescence escape, and maintains stemness in stem cells. These aspects of Wip1 signaling will be reviewed below and are summarized in Figure 4.
