PsyOPS combines multiple methods to identify genes that are likely to be causally implicated in psychiatric disorders.53 The method prioritised genes based on three criteria: mutational constraint (gnomAD probability of loss-of-function intolerance [pLI] > 0.99), brain expression (Human Protein Atlas “elevated in brain” designation), and association with neurodevelopmental disorders (from Genomics England gene panels for autism, intellectual disability, and epilepsy). The PsyOPS score is assigned based on prediction from a trained classification model. For each lead variant we selected the gene with the highest PsyOPS score, using nearest gene to break ties.
