Ingenuity® Pathway Analysis (IPA®) was used to perform pathway, canonical pathways, and causal network analysis. All genes that passed the threshold of significance at 25% FDR were included in the analysis Table 2.Table 2Results of GWAS enrichment analysis in modules correlated with alcohol dependence and alcohol consumptionRNA-Seq data (N = 138)GWAS dataModule trait correlationGWAS P 0.05, eQTL P < 5 × 10−8IDADPAuditPACPPGC-ADUKBB-ACTAG-CPDThistle2−0.289.00E-04−0.253.00E-03−0.229.00E-031.50E-02a1.30E-02a5.52E-01aBrown40.184.00E-020.141.00E-010.121.00E-014.20E-03b2.28E-01b4.81E-03bAD alcohol dependence, Audit audit scores, AC alcohol consumptiona Permuted P value for the left-tail Fisher’s exact test (under-enriched)b Permuted P value to test right-tail Fisher’s exact test (over-enriched)
