For each proband and first degree unaffected family members, iPSC were produced using the classical retroviral approach or by a viral-free episomal reprogramming method (Okita et al., 2011). The iPSC lines from families 1123 and 03 have been previously described (Abyzov et al., 2012), and the iPSC characterization for families 07 and 1120 is shown in Figure S1 and Figure S2.
