A secondary pheWAS analysis in BioVU using summary statistics of cannabis use disorder conditioned on smoking initiation revealed attenuated findings, with only ten codes now passing Bonferroni corrections; anxiety disorder, viral hepatitis, and several respiratory codes were still significant. When we conditioned the pheWAS on tobacco use disorder, some associations remained significant (respiratory conditions, viral hepatitis), whereas other associations (eg, anxiety disorder) were no longer associated with PRS for cannabis use disorder (appendix p 18).
