We used the ukb_gen_samples_to_remove() function from the R package ukbtools v0.11.354 to choose a subset of individuals within which no pair had a kinship coefficient exceeding 0.0884, equivalent of up to third-degree relatives. For each related pair, this function removes whichever member has the highest number or relatives above the provided threshold, resulting in a maximal set. Through this process, an additional 14,326 (4.74%) sequences were removed from downstream analyses.
