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Chunk #29 — RESULTS — Genetically informative research approaches and their limitations — Comorbidity with other psychiatric disorders

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Genetically informative research on adolescent substance use: methods, findings, and challenges.
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Not surprisingly, genetic influences on adolescent illicit drug use have been linked to a general predisposition to impulsivity, disinhibition and correspondingly, to externalizing behaviors.70 In adult samples drug dependence shares genetic influences with antisocial personality disorder and conduct disorder – for instance, Kendler et al 71 found that 64-86% of the genetic variation in these disorders was attributable to a common underlying factor.