The risk of developing ischaemic heart disease in Belfast in comparison with the French centres for the whole cohort (drinkers and non-drinkers) is given in table 5. Hazard ratios gradually decreased after successive adjustment for classic risk factors (age, centre, tobacco consumption, years of education, physical activity, systolic blood pressure, apolipoprotein A-1 and apolipoprotein B concentration, waist circumference, and treatment for hypertension, diabetes, and dyslipidaemia), drinking status, and wine drinking. The decreasing trend was more substantial for hard coronary events than for angina pectoris.