of data that were analyzed included 53 human tissue or cell type RNA-seq data from the Genotype-Tissue Expression Project (GTEx)54; 152 human, mouse, or rat tissue or cell type array data from the Franke lab;55 3 sets of mouse brain cell type array data from Cahoy et al.56; 292 mouse immune cell type array data from ImmGen57; and 396 human epigenetic annotations (6 features in 88 primary cell types or tissues) from the Roadmap Epigenomics Consortium52. In the analysis of each trait in each dataset, we used FDR < 0.05 to indicate significant enrichment for the h2 SNP.