Several familial risk factors remained significantly associated with class assignment after adjustment for offspring sociodemographics (Table 2). Sibling polydrug use was associated with membership in all affected classes, and sibling use of only marijuana or another drug with membership in the AUD class, as compared to the unaffected class. Maternal depression was associated with membership in the AUD and AUD-MDD-ANX classes, with evidence of an association with the SUD-CD class. The HG-HE risk group was significantly associated with membership in the AUD class, with evidence of an association with the SUD-CD class as compared to the unaffected class. More specific associations were observed for paternal externalizing disorder, which was associated only with the SUD-CD class, and for reports of sibling alcohol problems, which were associated only with membership in the AUD-MDD-ANX class.
