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Chunk #26 — Method — Incorporating the SNP Score in the Longitudinal Design

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The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption.
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Year of birth, cohort, sex, age of assessment, and the first ten genetic principal components were used as covariates in all SNP score association tests. Genetic principal components account for ancestry effects and were based on a subsample of 10,000 SNPs from sample founders (i.e., unrelated subjects) and computed in Eigenstrat (Price, et al., 2006). Scripts are available upon request.