cohort, a diverse sample of >165,000 veterans assessed for PTSD with re-experiencing symptoms [10], polygenic risk scores (PRS) derived from the PGC-PTSD study [9] were associated with PTSD re-experiencing symptoms in the MVP [10]. The MVP cohort is also an ancestrally diverse population, with 11% of their PTSD GWAS sample being of African ancestry. However, it is a military and predominantly male sample, with approximately 6% of the GWAS population being female [10]. Further, PTSD PRS derived from the PGC-PTSD study have been associated with PTSD in independent samples [11]. In addition, other studies have used alcohol use-related PRS to predict alcohol and other substance use disorders [12]. However, no study to our knowledge has used PTSD PRS to predict alcohol and other substance use disorders.
