Our fourth independent SNP (rs12461964; detected in the FINRISK2007 sample) is located 8.2 kb downstream of CYP2A6, has a high minor allele frequency (MAFFINRISK = 0.45) and a prominent effect size (beta = -0.61). Rs12461964 is in high LD with the top-SNP rs56113850 (D’ = 0.85); although it was identified as an independent SNP in conditional analyses in the FINRISK2007 sample, the detected association likely reflects LD with rs56113850.
