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Chunk #25 — Discussion

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
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these eQTLs might therefore also be present in other, non-blood tissues, as previously observed for rodents [47]–[49]. Indeed we could replicate some of these trans-eQTLs in a smaller dataset of four non-blood tissues. Importantly, as mentioned before [46], the allelic directions were nearly always identical to blood, which implies that trans-eQTLs, if also present in another tissue, work in the same way.