Simultaneous physiological monitoring in multiple regions will be necessary to further understand the role of interactions. Are there linked representations in distant populations during these network interactions that encode information regarding specific experiences? Task-relevant representations within the hippocampal and prefrontal cortex have been found to be inter-dependent [30,38], indicating that neural ensembles in these regions may act in concerted fashion to support memory-guided behavior. These early findings delineate physiological interactions that may serve to promote the emergence of joint representations of similar experiences. In addition, during SWRs, there is coordinated reactivation in the hippocampus and PFC, but whether this represents retrospective or prospective information, and how this reactivation depends on learning and behavioral state has to be elucidated. Simultaneous physiological monitoring during task phases that require cognitive elements linked to reactivation, such as retrieval, working memory and planning, will enable us to answer these questions.
