Alcohol use disorders (AUDs), which include alcohol abuse and dependence, are among the most common types of life-threatening neuropsychiatric disorders, impacting ~15% of the population (Sridhar, 2012; Grant et al., 2017; World Health Organization, 2019). Despite the high prevalence of AUDs, the precise molecular mechanism(s) that lead to the development of dependence and tolerance remain poorly understood (Lewohl et al., 2000; Hanchar et al., 2006). One limitation to our current mechanistic understanding of AUDs is the lack of an appropriate human model system that permits functional studies.
