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Chunk #9 — RESULTS — Dissection of the contribution of cis-effects to heritability of gene expression

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Mapping cis- and trans-regulatory effects across multiple tissues in twins.
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These results from multiple tissues indicate that a large proportion of the heritability of gene expression remains unexplained by the common SNPs (MAF > 5%) analyzed in standard cis-eQTL analyses. Thus, we asked whether there are other genetic cis-effects which account for the additional genetic variance of gene expression.