In the Addiction project, the majority of males and females fall into two very distinct clusters based on X and Y chromosome intensities. All samples annotated as males have a Y intensity greater than all samples annotated as females. Therefore, there is no evidence of gender misidentification. However, several samples (delineated by the dashed lines in Figure 1) are distinct from the majority of males and females. Two males with DNA samples from blood have an X chromosome intensity typical of females and a Y intensity typical of males. They appear to be XXY. One of these males has high X heterozygosity and might be mistaken for a female if X heterozygosity alone was used for checking gender. Four male samples (3 cell line and one blood) have unusually high intensities of the Y chromosome and may be either XYY or perhaps XY/XYY mosaics. Similarly, two males have a low Y intensity and may be XY/XO mosaics (one cell line, one blood). Several females have low X intensities and low X heterozygosity, indicating that they are XO or, perhaps more
