The total group of patients with substance dependence had a significantly higher mean total CTQ score than the controls: 48.7 (16.8) vs 36.5 (10.3); F(1,643) = 72, p < 0.0001. Further analysis showed that CTQ scores (mean (SD)) were higher in men with at least two addictions: no addiction (i.e. controls): 36.5 (10.3); one addiction: 46.1 (16.5); two addictions: 50.9 (16.8); three addictions: 49.2 (16.8); F(3,641) = 27, p < 0.0001. For further details see Supplementary Table 1.