Mental, neurological, and substance use disorders are a leading cause of the disease burden worldwide, substantially contributing to health loss across the lifespan. DALY rates are lower in developing compared to developed regions. However, population growth and a changing age profile are producing a shift in the disease burden from communicable to noncommunicable diseases and from YLLs to YLDs. This demographic and epidemiological transition is contributing to a rise in the burden of mental, neurological, and substance use disorders, particularly in developing regions.
